A previously-unrecognized motif of transcription factor RYBP, hotspot of cancer-related mutations, is essential for the integrity of Polycomb repressive complex 1
C. S. Silva, L. Marino Perez, I. Garcia Ferrer, I. Dieryck, O. Pessey, E. Boeri Erba, M. Ringkjobing Jensen, M. Marcia
This study identifies a critical RYBP motif in vPRC1 essential for complex stability and linked to cancer mutations, using AlphaFold2 and NMR.
bioRxiv · Oct 23, 2023 · PreprintBiochemistry