HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
Y. Kamada, Y. Ohnishi, C. Nakashima, A. Fujii, M. Terakawa, I. Hamano, U. Nakayamada, S. Katoh, N. Hirata, H. Tateishi, R. Fukuda, H. Takahashi, G. L. Lukacs, T. Okiyoneda
This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.
bioRxiv · Oct 16, 2023 · PreprintCell Biology