Modelling structural constraints on protein evolution via side-chain conformational states
U. Perron, A. M. Kozlov, A. Stamatakis, N. Goldman, I. Moal
The paper develops a structurally-aware substitution model for amino acid sequence evolution by incorporating side-chain conformational states, showing improved performance in divergence time estimation and tree inference.
bioRxiv · Jan 26, 2019Evolutionary Biology