Cancer BiologybioRxivPreprint
Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe
I. Tabet, E. Orhan, E. Candiello…·C. Theillet
This study shows BRCA1-deficient breast cancers are highly sensitive to gemcitabine, leading to ssDNA accumulation and mitotic catastrophe, which may enhance antitumor immune response.
DOI 10.1101/2023.10.31.564929