Author

I. Zehbe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

R. Jackson· 3 shared G. Dayer· 2 shared M. Togtema· 2 shared A. Faulkner· 1 shared A. Ortigas-Vasquez· 1 shared G. Hussack· 1 shared J. D. Lukacs· 1 shared J. Tanha· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

R. Jackson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting the Human Papillomavirus 16 E6 Oncoprotein with Antibodies

G. Dayer, A. Faulkner, T. Talwar, M. Togtema, I. Zehbe

This paper reviews anti-E6 antibodies and presents new Camelidae-derived single-domain antibodies that bind endogenous E6 but do not induce apoptosis.

bioRxiv · Oct 21, 2022 · PreprintCancer Biology

Human papillomavirus type 16 sub-lineages and integration in cancer

R. Jackson, A. Ortigas-Vasquez, I. Zehbe

The paper investigates HPV16 sub-lineages and integration in cancer using NGS data from clinical samples, finding variant-specific integration signatures related to hypoxia/energetics versus host immune abrogation and cancer pathways.

bioRxiv · Jun 25, 2020 · PreprintCancer Biology

The potentials and pitfalls of a human cervical organoid model including Langerhans cells

R. Jackson, J. D. Lukacs, I. Zehbe

The paper describes a human cervical organoid model incorporating Langerhans cells and provides a detailed protocol for its use in research.

bioRxiv · Oct 19, 2019Cell Biology

Single-domain antibodies represent novel alternatives to monoclonal antibodies as targeting agents against the human papillomavirus 16 E6 protein

M. Togtema, G. Hussack, G. Dayer, M. Teghtmeyer, S. Raphael, J. Tanha, I. Zehbe

This study identifies VHHs that bind HPV16 E6 protein with nanomolar affinity, offering potential as novel targeting agents for HPV16-related cancers.

bioRxiv · Aug 9, 2018Cancer Biology

Human Cervical Keratinocyte-Derived Monolayer and Organoid Cultures for Disease Modelling and Drug Screening

P. L. Villa, R. Jackson, S. Eade, N. Escott, I. Zehbe

This study establishes a reproducible method to grow cervical keratinocytes into monolayer and organoid cultures from patient biopsies, enabling disease modeling and drug screening.

bioRxiv · Jul 20, 2018Cancer Biology