PERTURBATION OF THE AMINO ACID STRESS RESPONSE PATHWAY EXPOSES A METABOLIC VULNERABILITY IN MULTIPLE AGGRESSIVE CANCER SUBTYPES
Evelien Peeters, Igor Fijalkowski, Sara T'Sas, Kasper Thorhauge Christensen, Jordy De Coninck, Els Van Ammel, Lasse Vleminckx, Kenneth Hofkens, Lore Mennes, Alexandra Reekmans, Kaat Durinck, Kesia Van Coillie, Eleonora Leucci, Maria Francesca Baietti, Jeroen Verstappe, , Steven Goossens
This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.
bioRxiv · Nov 3, 2026 · PreprintCancer Biology