Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Luca Ermini, Anuja Lipsa, Ann‐Christin Hau, Iryna Krokhmal, Bakhtiyor Nosirov, Réka Tóth, Eliane Klein, Anaïs Oudin, Linsey Houben, Sabrina Fritah, Christel C. Herold‐Mende, Katrin B. M. Frauenknecht, Michel Guy André Mittelbronn, Guy Berchem, Frank Hertel, , Anna Golebiewska
This study integrates multi-omics and functional drug screening in patient-derived organoids to identify personalized therapeutic vulnerabilities in adult high-grade gliomas, finding distinct drug responses in IDH1 mutant and MYCN-amplified tumors.
bioRxiv · Sep 9, 2025 · PreprintCancer Biology