Author

Isaac King

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jarron RoyiD· 1 shared Lauren MahoneyiD· 1 shared Luke Kalcheim· 1 shared Madeline Collins· 1 shared Nat MurreniD· 1 shared Otto A. KletzieniD· 1 shared Rebecca M. RichardsiD· 1 shared Sarah Geffe· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Jarron RoyORCID

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1 paper

Recent·Most cited

Disruption of the interferon-gamma axis limits chimeric antigen receptor T cell efficacy against acute myeloid leukemia

Nat Murren, Isaac King, Lauren Mahoney, Jarron Roy, Otto A. Kletzien, Madeline Collins, Sarah Geffe, Luke Kalcheim, Rebecca M. Richards

This study shows that blocking the interferon-gamma axis reduces CAR T cell effectiveness against AML by impairing antigen expression and cytotoxicity, suggesting caution with IFN-gamma inhibitors in AML treatment.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology