Large-Scale Mutagenesis Identifies Sequence Changes That Bias Tau Toward CTE-like Aggregation
Łukasz A. Joachimiak, Chad Dashnaw, Simran Rastogi, Nabil Morgan, Isaam Memon, Klaudia Jaczynska, Binh An Nguyen, Lorena Saelices, Charles L. White, Sarah H. Shahmoradian
The paper identifies sequence changes that bias tau aggregation toward CTE-like structures using mutagenesis and structural analysis.
bioRxiv · Oct 9, 2026 · PreprintBioengineering