Isabel C. Orbe

Leveraging the dominant-negative effect of the kuru-protective G127Vprion protein variant as a novel therapeutic strategy

This paper demonstrates that the G127V prion protein variant can prevent and suppress prion infection through a dominant-negative effect, suggesting its potential as a therapeutic strategy.

Lysosomal Enhancement Prevents Infection with PrPSc, α-Synuclein & Tau Prions

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities

The paper identifies immunodominant extracellular loops (ECLs) from Treponema pallidum FadL proteins that elicit antibodies with opsonic and growth-inhibitory activities against syphilis-causing spirochetes.