WRN deficiency generates oncogenic rearrangements at TA-rich tandem repeats
Meng Wang, Hui Pan, Anastasia Samarkina, Austin John Escobar, Noel Cruz Pacheco, Satoru Mizuhashi, Jamie D. Aquino, Katy K. Tsai, ADIL I. DAUD, Ivan EI-Sayed, Haruto Nishida, Sakuhei Fujiwara, Takashi Hirano, Sine Phelan, Allan O'Keefe, , Boris C. Bastian
This study shows WRN deficiency causes oncogenic rearrangements at TA-rich tandem repeats by destabilizing them, leading to chromosomal breaks and activation of TERT in melanoma.
bioRxiv · Oct 22, 2026 · PreprintCancer Biology