Human Choroid Plexus Organoids Progress to Postnatal-like Maturation and Reveal a Closing Window of Developmental Plasticity
Elizabeth Joy Apsley, See Swee Tang, Elisa Vitiello, Ivan Imaz-Rosshandler, Marian Fernández-Otero, Kyriaki Sapidou, Sean Anthony Burnap, Weston B. Struwe, Milos Pjanic, John F. Fullard, Jaroslav M. Bendl, Panos Roussos, Katherine R. Long, Fanni V. Gergely, Madeline A. Lancaster, Laura Pellegrini
This study uses single-cell RNA sequencing to track the maturation of human choroid plexus organoids and identifies a stage-dependent window of developmental plasticity.
bioRxiv · Oct 14, 2026 · PreprintDevelopmental Biology