Mitochondrial translation is a targetable dependency of chemo-refractory triple negative breast cancer
Mariah J. Berner, Steven W. Wall, Mokryun L. Baek, Audra Lane, Allison S. Greer, Karen Wang, Lacey Elizabeth Dobrolecki, Ivy Strope, Qian Zhu, Bing Zhang, Jonathan Thomas Lei, Michael T. Lewis, Gloria Vittone Echeverria
This study identifies OXA1L-dependent mitochondrial translation as a targetable dependency in chemo-refractory TNBC, showing that inhibiting it enhances chemotherapy sensitivity.
bioRxiv · Apr 18, 2026 · PreprintCancer Biology