Reprogramming protein interfaces between adenylation and carrier protein domains in nonribosomal peptide synthetases
Fumihiro Ishikawa, Iyo Arata, Taisei Uehara, Kana Kinoshita, Yuka Nakanishi, Kosei Sone, Toma Kashima, Fumitaka Kudo, Tadashi Eguchi, Tohru Terada, Shinya Fushinobu, Genzoh Tanabe, Akimasa Miyanaga
This study reprograms protein interfaces between adenylation and carrier protein domains in NRPSs to enable non-cognate pairings and enhance natural product production.
bioRxiv · Jul 22, 2026 · PreprintBiochemistry