SPEAK: Spatial Prompting with Expert Aligned Knowledge for Tissue Domain Identification in Spatial Transcriptomics
Huanhuan Wei, Xiao Luo, Hongyi Yu, J Liang, Luning Yang, Lixing Lin, Maor Sauler, Naftali Kaminski, Alexandra Popa, Xiting Yan
SPEAK identifies spatial domains in spatial transcriptomics data using a large language model and expert-aligned prompts, showing improved accuracy and interpretability.
bioRxiv · Jun 26, 2026 · PreprintBioinformatics