J. A. Dunkle

The structure of the SufBC2D-SufE complex reveals the mechanism of sulfur transfer in bacterial Fe-S cluster assembly.

This study determines the structure of the SufBC2D-SufE complex, revealing conformational changes that facilitate sulfur transfer in bacterial Fe-S cluster assembly.

Structural insights into target detection by the S. marcescens type III CRISPR complex and its deployment inSNP identification

The paper determines the structure of S. marcescens Type III CRISPR complex and shows it can detect SNPs in human transcripts associated with sickle cell disease.

Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets

The paper identifies Cas10 residues that distinguish cognate from mismatched target RNAs, enhancing interference specificity in Type III CRISPR systems.

Two conserved arginine residues facilitate C-S bond cleavage and persulfide transfer in Suf family cysteine desulfurases.

This study investigates the role of two conserved arginine residues in SufS, showing they are critical for persulfide transfer during iron-sulfur cluster biogenesis in E. coli.

The structure of the SufS-SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis

This paper presents the first X-ray structure of the E. coli SufS/SufE complex, revealing interactions critical for persulfide transfer in Fe-S cluster biogenesis.

Two dynamic, N-terminal regions are required for function in Ribosomal RNA Adenine Dimethylase family members

The paper identifies two N-terminal regions in RRAD enzymes critical for function, showing they promote rRNA binding and substrate positioning for methylation.

The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

The paper presents the structure of a Type III-A CRISPR-Cas effector complex from S. epidermidis, revealing interactions with target RNA and crRNA and highlighting differences among related systems.