ANGPTL8 R59W variant influences inflammation through modulating NF-κB pathway under TNFα stimulation
M. Abu-Farha, D. Madhu, P. Hebbar, A. Mohammad, A. Channanath, S. Kavalakatt, N. Alam-Eldin, F. Alterki, I. Taher, O. Alsmadi, M. Shehab, H. Arefanian, R. Ahmad, F. Al-Mulla, T. A. Thanaraj, J. Abubaker
This study shows the ANGPTL8 R59W variant increases TNF and IL7 levels and NF-κB activity through altered binding dynamics.
bioRxiv · Jul 4, 2023 · PreprintBiochemistry