J. Dickinson

Comparisons of two receptor pathways in a single cell-type reveal features of signalling specificity.

The paper compares two receptor pathways in Arabidopsis root endodermis cells, showing distinct outputs despite similar MPK phosphorylation patterns, suggesting specificity through combinatorial activation and cross-pathway inhibition.

Mucin granules are degraded in the autophagosome-lysosome pathway as a means of resolving airway mucous cell metaplasia

This study shows that autophagy degrades mucin granules in airway mucous cells during resolution of mucous cell metaplasia, offering a therapeutic target for airway diseases.

Analysis of patient derived xenograft studies in Oncology drug development: impact on design and interpretation of future studies

This paper compares model-based analysis and un-paired t-test for PDX xenograft studies, finding model-based methods more powerful and capable of detecting smaller treatment effects.