Transactive response DNA-binding Protein (TDP-43) regulates early HIV-1 entry and infection.
R. Cabrera-Rodriguez, S. Perez-Yanes, R. Gonzalez-Montelongo, J. M. Lorenzo-Salazar, J. Estevez-Herrera, J. Garcia-Luis, A. Inigo-Campos, L. A. Rubio-Rodriguez, A. Munoz-Barrera, R. Trujillo-Gonzalez, R. Dorta-Guerra, C. Casado, M. Pernas, J. Blanco, C. Flores, A. Valenzuela-Fernandez
This study shows that TDP-43 regulates HIV-1 infection by stabilizing HDAC6, reducing viral Env fusion and infection capacity in CD4+ T cells.
bioRxiv · Dec 6, 2021 · PreprintImmunology