Adapting antibacterial display to identify serum active macrocyclic peptide antibiotics
J. R. Randall, K. Groover, A. O'Donnell, J. Garza, T. J. Cole, B. Davies
This study identifies new macrocyclic peptide antibiotics active in human serum by screening a library under serum conditions, finding that sequence factors like length, charge, and disulfide bonds influence activity.
bioRxiv · Jul 28, 2023Microbiology