Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor
S. Huang, J. Girdner, L. P. Nguyen, D. Enard, M. M. H. Li
This study identifies a single residue in ZAP's WWE domain that enhances its antiviral activity against alphaviruses by improving viral translation inhibition.
bioRxiv · Nov 20, 2023 · PreprintMicrobiology