BK polyomavirus evades innate immune sensing by disrupting the mitochondrial network and membrane potential and by promoting mitophagy
J. Manzetti, F. H. Weissbach, G. Unterstab, M. Wernli, H. Hopfer, C. B. Drachenberg, C. H. Rinaldo, H. H. Hirsch
This study identifies BKPyV agnoprotein's role in evading innate immunity by disrupting mitochondria and promoting mitophagy, leading to viral persistence.
bioRxiv · Mar 19, 2020Microbiology