The IRE1α-endonuclease regulates PD-1 expression through a novel XBP1/miRNA-34a axis within Natural Killer cells
K. Bednarska, G. Thillaiyampalam, S. Mujaj, J. Nourse, J. Gunawardana, M. B. Sabdia, Q. Cui, L. M. de Long, F. Vari, M. K. Gandhi, A. S. Cristino
This study identifies a novel IRE1α-endonuclease regulated XBP1/miR-34a axis that modulates PD-1 expression in NK-cells, with implications for cancer immunotherapy.
bioRxiv · Feb 26, 2023 · PreprintCancer Biology