Cell BiologybioRxiv
Kinase inhibition of G2019S-LRRK2 restores autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
J. Obergasteiger, G. Frapporti, G. Lamonaca…·M. Volta
This study investigates how G2019S-LRRK2 mutation disrupts autophagy-lysosome pathway function and leads to alpha-synuclein accumulation, showing kinase inhibition can restore pathway function and reduce inclusions.
DOI 10.1038/s41420-020-0279-y