SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
C. Aloise, J. G. Schipper, A. van Vliet, J. Oymans, T. Donselaar, D. L. Hurdiss, R. J. de Groot, F. J. M. van Kuppeveld
This study identifies the SARS-CoV-2 nucleocapsid protein's N2b domain as inhibiting PKR-mediated integrated stress response and innate immunity by sequestering dsRNA.
bioRxiv · Sep 2, 2022Microbiology