Spatiotemporal coordination of Rac1 and Cdc42 at the whole cell level during cell ruffling
S. Hladyshau, J. P. Stoop, K. Kamada, S. Nie, D. V. Tsygankov
This study uses a simulation model to show that membrane velocity during cell ruffling is controlled by GTPase activation kinetics, not concentration, and that time delays between Rac1 and Cdc42 activation can be explained by feedback loops.
bioRxiv · Mar 31, 2023Cell Biology