CDK1 and PLK1 cooperate to regulate BICD2, dynein activation and recruitment to the nucleus as well as centrosome separation in G2/M
N. Gallisa-Sune, P. Sanchez-Fernandez-de-Landa, F. Zimmermann, M. Serna, J. Paz, L. Regue, O. Llorca, J. Luders, J. Roig
This study identifies CDK1 and PLK1-mediated phosphorylation of BICD2 as essential for dynein activation and nuclear processes during G2/M.
bioRxiv · Nov 4, 2021Cell Biology