Transgenic pyrimethamine resistant Plasmodium berghei as a model for in vivo anti-DHFR drug testing
P. Koonyosying, N. Jupatanakul, J. Vanichtanankul, T. Saeyang, C. Pethrak, J. Pengon, W. Tipsuwan, Y. Yuthavong, S. Kamchonwongpaisan, C. Uthaipibull
This study creates a transgenic Plasmodium berghei model with quadruple DHFR mutations to test antifolate drugs in vivo, showing P218's effectiveness against resistant parasites.
bioRxiv · Sep 30, 2020 · PreprintMicrobiology