ESCRT-III accumulates in micronuclei with ruptured nuclear envelopes
J. Willan, A. Cleasby, N. Flores-Rodriguez, F. Stefani, C. Rinaldo, A. Pisciottani, E. Grant, P. Woodman, H. Bryant, B. Ciani
This study shows ESCRT-III and CHMP7 protect against genomic instability in micronuclei by repairing nuclear envelopes but also generate cytosolic DNA that promotes inflammation in cancer cells.
bioRxiv · Dec 1, 2018 · PreprintCancer Biology