N-terminal sumoylation of centromeric histone H3 variant Cse4 regulates its proteolysis to prevent mislocalization to non-centromeric chromatin
Kentaro Ohkuni, Reuben Levy-Myers, Jack Warren, Wei-Chun Au, Yoshimitsu Takahashi, Richard E. Baker, Munira A. Basrai
This study identifies K65 as a SUMO site on Cse4 and shows that sumoylation regulates its ubiquitin-mediated proteolysis to prevent mislocalization and maintain genome stability.
G3 Genes Genomes Genetics · Feb 8, 2018Peer-reviewedMolecular Biology