Spatial multi-omics resolve epithelium-fibroblast gradients and highlight NESTIN-NOTCH1-expressing subepithelial fibroblasts during human pancreatic tumorigenesis
Maëlle Batardière, Myriam Iliana Ibanez-Rios, Abdelhakim Khellaf, Elham Dianati, Sarah-Slim Diwan, Maxence Pelloux, Alexandre Archambault-Marsan, Camille Beaussier, Jade Diwan, Sasha Sapon-Cousineau, Jumanah Baig, Shoukari Ayman, Zean Ghanmeh, Zhiyuan Yang, Melisa Farias Gonzalez, , Vincent Quoc‐Huy Trinh
This study uses spatial multi-omics to identify NESTIN-NOTCH1-expressing fibroblasts in IPMNs and their role in pancreatic tumorigenesis.
bioRxiv · Sep 9, 2026 · PreprintCancer Biology