3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe
Paul A. Yushkevich, Mónica Muñoz, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Alex Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, , Ricardo Insausti
This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.
bioRxiv · Jan 15, 2021 · PreprintNeuroscience