Glioblastoma-derived extracellular vesicles released after radiation promote cognitive impairment through NFκB-mediated microglial activation
Sara Macias Palacio, Nicole G. Rummel, James Campbell, David Allan Butterfield, Subbarao Bondada, Chi Wang, Abu Saleh Mosa Faisal, John Lee Villano, Björn Bauer, Daret K. St. Clair, Luksana Chaiswing
This study shows that radiation-induced glioblastoma-derived extracellular vesicles impair cognition by activating microglia via NFκB and causing neurotoxic H2O2 release.
bioRxiv · Jun 11, 2026 · PreprintCancer Biology