CMG2 interaction with actin is required for growth factor-induced chemotaxis in endothelial cells.
Fangfang Jiang, Raj Kumar Mongre, Jacob Truman, Raphaela de Oliveira, Ethan Hardy, Elliot Hardy, James Fowler, Chao Wang, Hsien‐Jung L. Lin, Zachary J. Rose, Ryan Kelly, P. Christine Ackroyd, Michael S. Rogers, Ken Christensen
This study identifies CMG2-actin interaction as essential for growth factor-induced chemotaxis in endothelial cells, showing that CMG2 binds F-actin to enable directional migration.
bioRxiv · Jul 21, 2025 · PreprintMolecular Biology