Author

James Hewinson

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:whole-exome sequencing· 2 Research Focus:phylogenetics / evolution· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Iñigo MartincorenaiD· 2 shared Luiza MooreiD· 2 shared Michael R. StrattoniD· 2 shared Peter J. CampbelliD· 2 shared Philip S. RobinsoniD· 2 shared Raheleh RahbariiD· 2 shared Tim H. H. CoorensiD· 2 shared Alex CaganiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Iñigo MartincorenaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Population-based analysis of POT1 variants in a cutaneous melanoma case-control cohort

Irving Simonin Wilmer, Raúl Ossio, Emmett M. Leddin, Mark Harland, Karen A. Pooley, Mauricio Gerardo Martil de la Garza, Sofia Obolenski, James Hewinson, Chi C. Wong, Vivek Iyer, John Taylor, Julia Newton‐Bishop, David Timothy Bishop, Gerardo Andrés Cisneros, Mark Martin Iles, , Carla Daniela Robles‐Espinoza

The paper analyzes POT1 variants in a melanoma case-control cohort, finding that pathogenic variants are a minor contributor to melanoma risk but should be screened in high-risk individuals.

Journal of Medical Genetics · Dec 20, 2022Peer-reviewedGenetic & Genomic Medicine

Elevated somatic mutation burdens in normal human cells due to defective DNA polymerases

Philip S. Robinson, Tim H. H. Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Ólafsson, Bernard C. H. Lee, Andrew R. J. Lawson, Henry Lee-Six, Luiza Moore, Mathijs Arnoud Sanders, James Hewinson, Lynn M. Martin, Claudia Maria Assunta Pinna, Sara Galavotti, , Michael R. Stratton

The paper shows that germline mutations in POLE or POLD1 lead to elevated mutation burdens in normal human cells and tissues, but do not cause premature aging or other phenotypic features beyond early-onset cancer.

Nature Genetics · Sep 30, 2021Peer-reviewedGenomics

Extensive phylogenies of human development reveal variable embryonic patterns

Tim H. H. Coorens, Luiza Moore, Philip S. Robinson, Rashesh Sanghvi, Joseph Christopher, James Hewinson, Alex Cagan, Thomas R. W. Oliver, Matthew D. C. Neville, Yvette E. Hooks, Ayesha Noorani, Thomas J. Mitchell, Rebecca Claire Fitzgerald, Peter J. Campbell, Iñigo Martincorena, , Michael R. Stratton

The paper reconstructs phylogenies of human development using whole-genome sequencing to show variable embryonic patterns and lineage asymmetries across individuals and tissues.

bioRxiv · Nov 25, 2020 · PreprintGenomics