Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal Expansion
Liu Daisy Liu, Seung Won Shin, Kevin M. Joslin, Chunyu Wang, James Pai, Rong Ma, Xinyu Xiang, Iain C. Clark, K. Christopher García
The paper develops LINC-seq to identify functional TCR-pMHC pairs by clonal expansion and deep mutational scanning, achieving high accuracy in recovering known cognate pairs and resolving co-evolutionary interactions.
bioRxiv · Aug 23, 2026 · PreprintImmunology