scRM: A single-cell foundation model trained on scRNA-seq reads
Dongze He, Rob Patro, Marcel Nassar, Haiyu Wu, Qi Yan, Glenn Xu, Kristof Torkenczy, Jamin Liu, Stefka Tyanova
scRM is a single-cell foundation model trained on raw scRNA-seq reads, showing that raw data pretraining is feasible and cost-effective compared to count-based models.
bioRxiv · Nov 2, 2026 · PreprintBioinformatics