Mechanistic Basis for Microhomology Identification and Genome Scarring by Polymerase Theta
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard Dean Wood, Jeff J. Sekelsky, Gaorav P. Gupta, Steven A. Roberts, Dale A. Ramsden
This study elucidates how DNA Polymerase Theta identifies microhomologies during repair and shows how this process leads to genomic scars in cancer.
Proceedings of the National Academy of Sciences · Mar 31, 2020Peer-reviewedMolecular Biology