Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors
Sohum Mehta, Nidhi A. Thaker, Kengo Adachi, Christopher Y. Ko, Bian Liu, Sai S. Divkaruni, Oguz Can Koc, Anne C. Lyons, Samantha A. Sanchez, Pauline Löffler, Yoshihisa Nakahata, Jody L. Martin, Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, , Jin Zhang
The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.
bioRxiv · May 22, 2026 · PreprintBioengineering