Shared trans-ancestry architecture of HLA-mediated disease risk in the All of Us Research Program
Alison A. Motsinger‐Reif, Kwangmi Ahn, John S. House, Adam Burkholder, Tam Tran, Joseph H. Breeyear, Cristina Justice, Jacqueline Durney, Alyssa Jones, Parker Reyes, Matthew Bailey, Mary Davis, Anthony Vicenti, Jason Karnes, Jill A. Hollenbach, , Joshua C. Denny
The paper analyzes HLA variation across six ancestry groups in the All of Us Research Program to identify HLA-phenotype associations and assess ancestry-specific genetic architecture.
medRxiv · Jun 30, 2026 · PreprintGenetic & Genomic Medicine