Sequence-to-function deep learning decodes human cis-regulatory evolution
Riley J. Mangan, Nikitha Thoduguli, Dimitar Ivanov, Bessie Li, Krish Vasudev, Tom Zeerow, Jayashabari Shankar, Yuru Lin, Zunpeng Liu, Martin Wohlwend, Janet H. T. Song, M Kellis
This study uses sequence-to-function deep learning to identify lineage-specific cis-regulatory elements in human evolution, finding they are shorter, less conserved, and enriched in neurodevelopmental pathways.
bioRxiv · Aug 27, 2026 · PreprintGenomics