Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug Repurposing
He Dong, Frederick S. Vizeacoumar, Yue Zhang, Nicholas Jette, Jared D. W. Price, Vincent Maranda, Lihui Gong, Tanya Freywald, Jeff Patrick Vizeacoumar, Mary Lazell-Wright, Saruul Uuganbayar, Jaylynn Quail, Alain Morejon Morales, Ayaan Rizvi, Rani Kanthan, , Franco J. Vizeacoumar
This paper uses patient-derived pancreatic cancer organoids to identify drug sensitivities linked to tumor differentiation and pathway mutations, revealing new therapeutic targets in chemoresistant tumors.
bioRxiv · Dec 3, 2025 · PreprintCancer Biology