Gain-of-function mutations in the UNC-2/CaV2α channel lead to hyperactivity and excitation-dominant synaptic transmission in Caenorhabditis elegans
Yung-Chi Huang, Jennifer K. Pirri, Diego Rayes, Shangbang Gao, Ben Mulcahy, Jeff Grant, Yasunori Saheki, Michael M. Francis, Mei Zhen, Mark J. Alkema
This study identifies a gain-of-function mutation in the UNC-2/CaV2α channel in C. elegans that causes hyperactivity and excitation-dominant synaptic transmission by altering cholinergic and GABAergic transmission.
eLife · Jul 31, 2019Peer-reviewedNeuroscience