Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.
Vivax Sporozoite Consortium, Ivo Muller, Aaron R. Jex, Stefan H. I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J Emery-Corbin, Sarah Charnaud, Jeffrey Smith, , Vorada Chuenchob
This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.
bioRxiv · Dec 3, 2018 · PreprintMicrobiology