Aging, HIV Status, and Sex Differentially Influence Antiretroviral Therapy Disposition Pathways in Rectosigmoid Tissue and Peripheral Blood Mononuclear Cells
Hannah N. Wilkins, Cory J. White, Ruohui Zheng, Labib A. Mamun, Colten D. Eberhard, Edward J. Fuchs, Jennifer Hoffmann, Ekta Gupta, Ben Orsburn, Craig W. Hendrix, Namandjé N. Bumpus, Dionna W. Williams
This study identifies how aging and HIV status differentially affect antiretroviral therapy disposition pathways in rectosigmoid tissue and PBMC, with aging causing broader changes in drug-related proteins.
bioRxiv · Nov 6, 2026 · PreprintPharmacology & Toxicology