MicrobiologybioRxivPreprint
Single dose alum adjuvanted RBD protein vaccine provides protection against homologous challenge with SARS-CoV-2 Washington strain and heterologous rechallenge with Delta and Omicron BA.5 variants in K18 hACE2 mouse model
Rajesh Thippeshappa, Viraj Kulkarni, Varun Dwivedi…·Ricardo Carrion
A single dose of alum-adjuvanted RBD protein vaccine from the Wuhan strain protects against homologous SARS-CoV-2 WA strain challenge but not heterologous Delta and Omicron BA.5 rechallenge, unless mice survive the initial WA challenge.
DOI 10.1101/2025.09.18.677166