HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2
Jenna Clements, Sung Yun Jung, Ji Cao, Lei Sun, Ana Carolina Ghezzi, Mitchell Gaylen, La'Quan Reid, Changmin Peng
This paper shows HDAC11 de-fatty acylates SF3B2 at K10, altering its pre-mRNA binding and promoting AR-v7 splicing in HCC cells, but not in prostate cancer cells.
bioRxiv · Feb 23, 2026 · PreprintMolecular Biology