A Systematic Comparison of Single-Cell Perturbation Response Prediction Models
Lanxiang Li, Yue You, Yunlin Fu, Wenyu Liao, Xueying Fan, Shihong Lu, Ye Cao, Bo Li, Wenle Ren, Jiaming Kong, Shuangjia Zheng, Jizheng Chen, Xiaodong Liu, Luyi Tian
The paper benchmarks 13 models for predicting single-cell perturbation responses across 25 datasets, finding performance varies with perturbation effect size and evaluation metric.
Science Advances · Sep 9, 2026Peer-reviewedBioinformatics