Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
Emma D. Wrenn, Jacob C Harris, April Ann Apfelbaum, Jonah R. Valenti, Patricia A. Lipson, Stephanie I. Walter, Nicolas M. Garcia, Aya Miyaki, Steven C. Chen, Jim M. Olson, Jason P. Price, Kelly M. Bailey, Elizabeth R. Lawlor
The paper identifies TGFβ2 as a driver of a hybrid transcriptional state in Ewing sarcoma cells, promoting metastasis through ECM deposition and invasion.
Science Advances · Jan 21, 2026Peer-reviewedCancer Biology