SOX2 can associate with chromatin directly by binding to DNA or indirectly via association with other chromatin-bound proteins
Briana D. Ormsbee, Kabhilan Mohan, Ethan P. Metz, Phillip J. Wilder, Jimmie Persinger, Soumi Basu, Daisy V. Gonzalez, T.H. Tahirov, Donald W. Coulter, Sandipan Brahma, Angie Rizzino
This study shows SOX2 can regulate gene expression both directly via DNA binding and indirectly through interactions with other chromatin proteins.
bioRxiv · Sep 3, 2026 · PreprintMolecular Biology